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These treatments are typically suited for acute pain rather than long-term discomfort, leading researchers to investigate alternative strategies

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For example, in human PAECs under hypoxic conditions, the levels of ROS were increased, while the levels of mitochondrial thioredoxin 2, an antioxidant protein, were reduced which could contribute to exacerbating hypoxia-induced ROS production [157]

Additionally, we provide evidence that targets are degraded by proteasomal colocalization in a ubiquitin-independent manner and that degradation involves the interaction of the ligand with the protein target

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