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In vitro model for evaluating drug transport across the bloodbrain barrier

Cureus 16(5):e60545

Total glucosides of paeony ameliorates oxidative stress, apoptosis and inflammatory response by regulating the Smad7-TGF- pathway in allergic rhinitis

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Its pharmacokinetic profile with alternative dosing has not been modeled or studied

Acidic pH impairs the activity of the mitochondrial L-2-HG removal enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) and enhances the protein stabilization of HIF-1, leading to its escape from the degradation pathway 90