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Other key signaling pathways that are utilized are the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathways, as well as SH2B1, a scaffold protein that interacts with JAK2 and mediates GH-induced changes in the cytoskeleton

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68 Beyond hepatic processes, alterations in gut microbiota composition and impairment of the gut-liver barrier are key contributors to MASLD pathogenesis

Djafarian, J

Hiratake J

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