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The clearest wins are folate and vitamin D, on top of a healthy diet, a healthy weight, and not smoking

10.1016/j.ebiom.2018.12.062 105 WangL

Body Areas that Encounter Skin Pigmentation: Areas like elbows and knees are often pigmented, and you also get significant pigmentation on the toes where the footwear could be chafing against the skin

Researchers call this the "L-Arginine paradox" and attribute it to factors such as enzyme compartmentalization, the role of endogenous inhibitors (such as ADMA), and individual variation in amino acid metabolism

It might mean changing the agonist profile to engage slightly different receptor pathways

That said, GHK-Cu has a legitimate and valuable role in weight loss protocols, just not the role most people are searching for