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The doses approved by regulatory bodies have been determined through rigorous phase III clinical trials involving thousands of participants, with careful assessment of both efficacy and safety profiles

Peptide 20, a GIPR/GLP-1R/GCGR triagonist (currently in phase 1 clinical trial) 17 with balanced potency at the three receptors, is evolved from a GLP-1R/GCGR dualagonist 18 through iterative sequence refinement and modification (Fig

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Retatrutide is an investigational drug being developed for weight management and type 2 diabetes treatment

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