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Independent phase-variable expression has also been observed in genes involved in haemoglobin-haptoglobin acquisition (Phillips et al., 2022) which is hypothesised to provide an adaptive response to fluctuations in haem-iron availability/source influenced by the stage or site of infection (Rao et al., 1999

The researchers have suggested that such expansion will prove essential to determine whether the observed signals reflect global patient experience or platform-specific dynamics with the inherent risk of confounding factors such as confirmation bias

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