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296 The presence of mutHTT and the accumulation of mtDNA mutations caused by inadequate mitophagy and decreased biogenesis impair oxidative phosphorylation, enhance the formation of reactive ROS, and lower ATP production

doi: 10.1007/s11892-014-0552-7 44 KorposKadriNKappelhoffRWegnerJOverallCMWeberEet al

Future Directions While preclinical data are compelling, human trials are needed to validate efficacy and dosing

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