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Reactive oxygen species as mediators of cellular senescence

You should not use GLP-1 medications if you have: Personal or family history of medullary thyroid cancer Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Previous severe allergic reaction to semaglutide or liraglutide Current pregnancy or planning to become pregnant History of pancreatitis (requires careful evaluation) Severe gastrointestinal disease Additionally, these medications are not typically recommended for patients under 18 years old, though Saxenda has some pediatric approval for adolescents 12 and older with obesity

Zhang et al., 2016

It reduces cardiovascular events in patients with heart disease

This statement, published in the peer-reviewed Journal of Endocrinology and Metabolism, represents the consensus finding across all six trials and nearly 900 participants

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