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Individual variations in intrinsic factor production, genetic polymorphisms affecting B12 metabolism, and the complex interactions between various nutrients and medications can influence B12 status

J.Ghosh-ChoudhuryG.KhazimK.et al

Hou et al., 2018)

Free Cu2+ is toxic (Fenton reactions, hydroxyl radicals), but the GHK-Cu complex is stable, diffusible and delivers copper in a targeted manner to copper-dependent metalloenzymes: lysyl oxidase (collagen/elastin crosslinking), Cu/Zn superoxide dismutase (SOD1, antioxidant defence), tyrosinase (controlled melanogenesis), dopamine-beta-hydroxylase