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Because IGF-1 is involved in the hearts response to injury, improves contractility, and reduces cardiac fibrosis, it could be used to improve heart function after myocardial infarction

Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

Separate vials allow independent dose control, which matters for TB-500-heavy injury protocols, but they require more injections per session and three reconstitutions

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Uncommon Side Effects Less frequently reported effects include mild lightheadedness (potentially copper-related), temporary nausea or headache that typically resolves within hours, and rare transient fatigue at higher doses

This may influence the overall conclusions drawn from this review and caution should be exercised in interpreting the results