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The marked increases in protein levels of BNIP3, P62, and PARKIN were clearly observed in the tibialis anterior muscle of mice with castration (112), and the increased ratio of LC3 II/LC3 I in mice with hypogonadism, which indicates a strong association between androgen deficiency and enhancement of mitophagy (113)

Avoiding addictive ultra-processed food, which is designed to drive overconsumption, is also essential. Dr Earim Chaudry, NHS GP and chief medical officer at Voy, also suggests reducing the dose of weight-loss drugs in addition to making lifestyle changes

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By increasing dopamine availability, tesofensine may reduce the reward-driven eating behaviors that contribute to overconsumption Norepinephrine involved in alertness, energy, and the fight-or-flight response

It is still important to monitor your thyroid antibodies and hormone levels to ensure your overall treatment remains balanced

Further RTCs are warranted to validate these findings and identify specific subgroups of KTRs who would benefit most from GLP-1 RA therapy