By boosting these normal reactions, GLP-1 medications help people manage their diabetes better and lose weight more effectively
in Agricultural Economics, Oklahoma State University M.S
Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users
Data on administration of GLP1-Ras before surgery were available for 396 (93%) patients, of whom 393 (92%) had continued their usual treatment regimen with the GLP1-RA up to the day of surgery
However, headache incidence rates were similar between AOD-9604 and placebo groups, suggesting that many cases represented background occurrence rather than treatment-related effects
At the same time, aggressive exfoliation can make inflamed skin angrier