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Fourth, as diabetes itself predisposes individuals to neurological complications, confounding from disease progression cannot be excluded in this disproportionality analysis

Pancreatic amylin as a centrally acting satiating hormone

*Correspondence: Qiyuan Keith Liu, [email protected]

As per Bradford Hills criteria 41 , the biological plausibility through GLP-1R expression in the nervous system and temporal consistency in time-to-onset analysis support potential causality, but confounding factors inherent to spontaneous reporting systems preclude definitive conclusions

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The first experiments demonstrating effects of peripheral GLP-1 in humans were published by Flint et al