Prescribers most often recommend Wegovy to support weight loss for people living with obesity
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Doses above 3,000 mg/day may cause GI side effects: nausea, diarrhea, abdominal cramps, and a fishy body odor (from trimethylamine production by gut bacteria) If you have kidney disease: L-carnitine clearance is renally dependent
They lower blood glucose levels, slow gastric emptying, lower serum cholesterol and triglyceride levels, reduce liver fat content, decrease the highly inflammatory visceral fat, enhance microvascular (!) blood flows in the muscle tissue, reduce muscle-produced inflammation, microglial activation (neuroinflammation), and enhance neuroplasticity
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Tirzepatide activates two receptors: GLP-1R and GIPR (glucose-dependent insulinotropic polypeptide receptor)