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Some studies use an insufficiency threshold, in addition to a deficiency threshold

Deeper depths (1.0-1.5mm) trigger stronger wound healing responses that may independently stimulate follicle activity

Some individuals may struggle to absorb enough B12 from their diet, especially those with conditions like pernicious anemia, certain gastrointestinal disorders, or those taking medications that impact absorption

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And surgeries and radiation therapy can cause injuries to tissue, sometimes even at the microscopic level

Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)