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When PT-141 binds to MC4R, it stimulates the release of neurochemicals involved in sexual responses, such as dopamine
This results in a lower ability to promote receptor internalization compared with endogenous GLP-1, so it allows to have an increased GLP-1R expression on the cell surface, which translates in more robust insulinotropic properties, possibly explaining the enhanced insulin secretion (in both diabetic and not diabetic human islets), induced by TZP ( Figure 1 )
& Kligman, A
When you eat, GLP-1 levels go up, which then tells your pancreas to release insulin
Food Chem 372:131335
Another important player in the regulation of autophagy is the activity-dependent neuroprotective protein (ADNP) [290] discovered by Gozes group in 1999 [291]
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