In addiction medicine, a lot of treatments target just one thing for example, a nicotine patch helps with smoking, but not alcohol but there is no medication that works across addictive substances, let alone all of them, said senior author Ziyad Al-Aly, MD, a WashU Medicine clinical epidemiologist and Chief of the Research and Development Service at the VA Saint Louis Health Care System
The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination
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