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First, differences in design, individual characteristics, and follow-up duration among the included meta-analyses may contribute to heterogeneity in the results, particularly in the context of patients prior medication history

Harno E, Cottrell EC, Yu A et al (2013) 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors still improve metabolic phenotype in male 11beta-HSD1 knockout mice suggesting off-target mechanisms

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For some GLP-1 users, gastrointestinal issues like cramps or constipation can occur

Results Twenty-three trials enrolling a total number of 181,143 participants were included