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The GLP-1 pathway plays a key role in controlling blood sugar and appetite, while the GIP pathway improves how cells respond to insulin

According to the FDA-approved labels, the most frequently reported adverse reactions include gastrointestinal symptoms such as nausea, vomiting, diarrhea, abdominal pain, and constipation

doi: 10.1016/j.cell.2017.09.044

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soft scald and bitter pit), or involve browning of entire internal portions of the pulp (internal breakdown) or of the fruit core (brown core) (Gapper et al., 2023