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Defective placentation leads to placental hypoxia and reperfusion injury due to ischemia and the resultant OS triggers the release of cytokines and prostaglandins, which results in endothelial cell dysfunction and plays an important role in the development of pre-eclampsia [77, 78]
The analysis integrates findings from preclinical investigations, limited clinical data, and regulatory perspectives
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Finally, the statement of Marshall Urist, the BMPs concept founder, about the mechanism of the release from BMP delivery system to mesenchymal cell receptor mechanisms as obscure and under intensive investigation in academic and industrial laboratories (Urist, 1996) is true also nowadays, and it can be generally applied to any of the peptide + carrier complexes
The timing was
