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Native IGF-1 exists predominantly bound to IGF-binding proteins (IGFBPs) in circulation, which sequester the growth factor and limit its bioavailability to target tissues

Patients with Normal Intestinal Absorption: Where the oral route is not deemed adequate, initial treatment similar to that for patients with pernicious anemia may be indicated depending on the severity of the deficiency

This injectable medication works by mimicking the action of a naturally occurring hormone in the body called glucagon-like peptide-1 (GLP-1)

They may also be used to treat certain medical conditions that interfere with the absorption of vitamin B12 from the diet

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Neelakantan H, Brightwell CR, Graber TG, et al