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The four DPP-IV-resistant amino acid substitutions extend bioavailability to ~30 minutes, enabling a sustained window of GHRH-R activation per dose

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The spent medium was collected after incubating iRBCs at a 5% hematocrit and parasitemia ranging between 34.7% in cRPMI for 24 hours and processed for MS anaylsis as described under Methods

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However, in patients with CLF, an improvement in recurrent bouts of HE was shown, while the treatment was well tolerated and was shown to be superior to placebo [71]