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Occasionally in severe cases, the muscles on the front of the palm at the base of the thumb (thenar eminence) can waste, causing hollowing, this is shown in the photograph below

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

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For quantitative assessment of Nrf2 translocation from the cytosol to the nucleus, an automated Cellomics ArrayScan (Thermo Fisher) microscope system was employed

Cell 181 , 8191 (2020)