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Endogenous GLP-1 has a half-life of 2 minutes, as dipeptidyl peptidase enzymes rapidly inactivate incretin hormones
Scientists developed it as a triple hormone receptor agonist , meaning it activates three different metabolic pathways in the body
But it almost certainly reduces the gastrointestinal rebound effects that some researchers report after abrupt cessation, including paradoxical increases in appetite, changes in bowel habits, and blood sugar fluctuations
The maximum dose studied in clinical trials is 12 mg once weekly
M.GreenwayF
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