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The hydrolysis of amides is catalysed by amidases, and peptidases

This knowledge led to the hypothesis that increased levels of Gsto2 in iSPNs can disrupt AA homeostasis, leading to changes in TH protein levels and increased DA synthesis in striatal projecting mDA neurons that potentially express no or low TH in the adult brain

However, our body's natural production of glutathione can decline due to various factors, including aging, stress, poor diet, and exposure to pollutants

It stimulates growth factors like VEGF and TGF-1, crucial for tissue repair and regeneration

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IL1-induced JAK/STAT signaling is antagonized by TGF to shape CAF heterogeneity in pancreatic ductal adenocarcinoma