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reported that, different from in vitro assay, as l-cysteine is present in micromolar concentrations in the intracellular environment, the activity of -glutamyl phosphate reductase (GPR) encoded by PRO2 in eukaryotes or proA in prokaryotes must be shut off to allow -GC formation from -glutamyl phosphate [12]

That means non-injectable GHK-Cu is being evaluated under the 503A interim policy, but injectable GHK-Cu should not be described as part of that same Category 1 pathway

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This results in the accumulation of cytosolic Ca 2+ followed by activation of synaptic vesicle exocytosis, and release of neurotransmitters

Cells were then selected and maintained in culture media containing 1 g/mL of puromycin

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