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MOTS-c has a particularly strong influence on skeletal muscle, which is a primary target tissue for its action

If GLP-1 is detectable in synovial fluid, that supports the biological plausibility that GLP-1-based therapies could potentially act directly in the joint as well as systemically. Tue Wenzel Kragstrup, MD, PhD After comparing participants blood and joint fluid samples to those from healthy volunteers, researchers detected small amounts of the bodys natural GLP-1 hormone in joint fluid

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Gut-brain axis signaling: The gut communicates with the brain through hormones such as GLP-1, peptide YY (PYY), and cholecystokinin (CCK)