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[3] Research published by the NIH: National Library of Medicine indicates that people with MTHFR mutations may require higher folate intake to maintain optimal homocysteine levels and overall methylation processes.[4] A study in JAMA Psychiatry suggested an association of individuals with MTHFR function and reports of mood

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The MTHFD1 encoded enzyme possesses three activities that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase