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patient education onboarding improves uptake Gut-Brain Axis, Neuroinflammation, and Metabolic Health Neuroimmune interface: Vagus nerve afferents (gut-to-brain), enteric neurotransmitter production (serotonin), immune cytokines crossing BBB, microbiota metabolites (SCFAs) modulating CNS function Neuroinflammation Microglial activation (TNF-, IL-1, IL-6, ROS, glutamate excitotoxicity) drives bystander damage and underpins neurodegenerative disease progression.n Leaky gut/leaky brain Zonulin-regulated tight junction breakdown

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