This is why weekly dosing works: the old dose is still partially active when you inject the new one, creating a steady therapeutic window
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We propose that the effects of an incretin-based therapy (tirzepatide) on food preoccupation may be associated with modulation of aberrant activity within this key hub of human mesolimbic circuitry
(This aligns with the labels gradual escalation to promote tolerability.) When to consider dosage adjustments Dose decisions are medical decisions, but there are common checkpoints to discuss with your clinician: Youve been on your current dose at least 4 weeks, side effects have settled, and your weight trend has flattened despite steady habits
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