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Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha

Gastrointestinal adverse effects, initially viewed as limiting, were ultimately managed through dose titration and formulation design

Our hypothalamic transcriptomics data revealed upregulated receptors, including calcitonin receptor, NPY2 receptor, and MC4R, providing insights into the neural mechanisms underlying metabolic dysregulation in Bbs5 / mice

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The kidney tells a similar story

Progress: They began at 456 lbs and reduced to 356 lbs, attributing much of their success to the medication