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Some people report slightly reduced appetite suppression on day 7 or 8, but this is generally minimal, especially at higher doses where you can reference the standard unit conversions to confirm your levels

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In order to compare the no/low CKD risk group and the CKD group, the two-tailed unpaired t test and the two-tailed MannWhitney U test were used for quantitative variables following parametric or non-parametric distribution, respectively