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That's metabolically active and produces inflammation (Goldberg, 2023)

Dual-regulating natural products synchronously regulate immune responses and metabolic activities by targeting hub molecules such as mTOR and SIRT1: they synchronously inhibit Tfh cell differentiation and HIF-1-mediated glycolysis, or form anti-inflammatory-metabolic protective synergistic effects by intervening in the TXNIP/NLRP3 inflammatory axis and PINK1/Parkin mitochondrial homeostasis, thereby effectively blocking the vicious cycle of immune activation-metabolic disorder-vascular remodeling

Gastrointestinal considerations: Both medications can affect the gastrointestinal system, though through different mechanisms

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Indoxyl sulfate affects glial function increasing oxidative stress and Neuroinflammation in chronic kidney disease: interaction between astrocytes and microglia

To understand the effect of a drug, it has to be measured against something else