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doi: 10.1001/jamainternmed.2016.2417

Instead, she recommends companies focus on making claims focused on supporting health pathways

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PA requires a documented T2D diagnosis and evidence of metformin step-therapy or a documented contraindication

The primary mechanism of action involves: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood sugar levels without causing hypoglycaemia when glucose levels are normal [3] [4] Suppressing glucagon release , thereby reducing glucose production by the liver Slowing gastric emptying , which prolongs the feeling of fullness after meals Acting on appetite centres in the brain , particularly the hypothalamus, to reduce hunger and food intake When administered as medication, GLP-1 receptor agonists mimic these natural effects but with enhanced duration and potency

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