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Propranolol HCL is a beta blocker used for conditions such as high blood pressure, angina, certain heart rhythm problems, essential tremor, and migraine prevention

Systemic FXR agonists such as OCA may cause dyslipidemia and pruritus, while selective intestinal FXR activators like Fexaramine can avoid direct hepatic activation, circumvent related toxicity risks, and significantly improve obesity and insulin resistance in animal models ( TGR5 is mainly expressed in enteroendocrine L cells of the distal ileum and colon and can be activated by bile acid agonists, including natural bile acid analogs (such as DCA) and synthetic small-molecule agonists (such as INT-777)

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Pediatr Nephrol 28:129133 O'Shea MH, Miller SB, Hammerman MR (1993) Effects of IGF-I on renal function in patients with chronic renal failure

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