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Factors that can trigger or worsen melasma include: Adopting a melasma-friendly lifestyle, including sun avoidance, stress management, anti-inflammatory nutrition, and hormone balance, can significantly support treatment success

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Finally, early injection of tranexamic acid before admission and during hospitalization can reduce plasma syndecan-1 levels, alleviate endothelial glycocalyx damage, and enhance vascular repair mechanisms [131, 132]

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70 DPN and diabetic autonomic neuropathy, especially cardiovascular neuropathy (CAN) are the most common and well-studied forms of neuropathy