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Pharmacy benefit managers have generally not added oral GLP-1s for obesity to their formularies, so most utilization has come from patients paying out of pocket.

2008 May;80(2):231-7

doi: 10.1530/JME-20-0078 25 ArakawaYWatanabeMInoueNSarumaruMHidakaYIwataniY

A pharmacokinetic study in growth-hormone-deficient patients using a closely related long-acting IGF-1 preparation found a terminal half-life of 5.8 hours for free IGF-1 after subcutaneous dosing, though the exact value for the research-grade LR3 analogue varies by formulation [4]

Ipamorelin is a synthetic pentapeptide built around an Aib residue and D-amino acids for protease stability

doi: 10.2147/JIR.S492079 185 YunH