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Both patients and practitioners involved with GLP-1 RAs tend to agree

[42] Tricyclic antidepressants: Tricyclic antidepressants disrupt the normal movement of the intestines (peristalsis) of the GI tract

they need clinical oversight that understands the delicate balance of metabolic health

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Seek immediate medical attention (A&E or call 999) if you develop: Severe, persistent abdominal pain radiating to the back (potential pancreatitis) Bloody or black, tarry stools Persistent vomiting with inability to keep down fluids Signs of severe dehydration or altered consciousness Symptoms of bowel obstruction (severe bloating, inability to pass gas or stool, severe cramping) For urgent but non-life-threatening concerns outside of GP hours, contact NHS 111 for advice

The combination shows promise in reducing pregnancy-related nausea under medical supervision