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The incretin effect is reduced in people with T2DM, mainly because GIP has less of an impact [85]

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Gln metabolism can maintain prostate cancer stem cells (CSCs) through -KG-dependent chromatin dioxygenase

Similarly, a recent cross-sectional study in healthy nurses found that NS workers had significantly lower plasma melatonin levels compared to DS workers, alongside trends toward altered leptin, ghrelin, and metabolic parameters, supporting the role of circadian disruption in predisposing to metabolic syndrome, which is a risk factor for BC development 175