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10.1016/j.brainres.2010.03.090 Brain Res

Employ Opioid-Sparing Anesthesia Protocols: Favor multimodal, opioid-sparing analgesic techniques and consider regional anesthesia blocks where appropriate, adhering to Enhanced Recovery After Surgery (ERAS) principles to minimize respiratory depression risk (Balasubramaniam et al

Staying well-hydrated is crucial, particularly if experiencing vomiting or diarrhea, though large volumes of fluid with meals should be avoided as this may worsen symptoms

Maintain accurate batch documentation and follow established contamination control protocols during handling

While human research remains limited, the consistency of animal findings supports the mechanism

This method did however not distinguish COL IV located in the gonad basement membrane around the DTC from any unsecreted COL IV, which largely appeared as intracellular blobs (Fig.2a, Supplementary Fig