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doi: [AASLD] Kaplowitz N

Because it is a substance naturally produced by the body, it is generally well-tolerated for daily use

As the largest immune organ, intestinal mucosa rapidly senses exogenous particles and can transmit inflammatory signals to the brain via vagal and cytokine-mediated pathways [12]

10.1017/S0007114513000068 68 MikusN.MarszaekK.PodlachaM.IqbalA.PuchalskiC.wiergielA

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Among the mAbs that bind to the extracellular domain of c-MET, the fully humanized monovalent mAb onartuzumab (MetMAb, Genentech, South San Francisco, California, USA) has been evaluated in several clinical trials, but failed to show improvement when given in combination with erlotinib in patients with MET -positive NSCLC [21, 22, 99]