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The tissue-specific distribution of beta-3 receptors (concentrated in fat tissue) further enhances selectivity

Glutathione's skin lightening effect is thought to be due to several reasons: 1- its antioxidant properties, 2- its ability to switch eumelanin production to pheomelanin (the type of melanin found in people with lighter skin tones), 3- its inhibitory effect on tyrosinase (a key enzyme in melanogenesis)

Similarly, dim light during the dark phase accelerated tumor onset and growth in tamoxifen-treated breast cancer xenografts, alongside reduced melatonin levels 162

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American Medical Association annual meeting

Age-related cochlear synaptopathy: An early-onset contributor to auditory functional decline