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Drug Interactions Major interactions: Non-selective MAO inhibitors (Phenelzine, Tranylcypromine) hypertensive crisis risk Increased dopaminergic effects with: Levodopa Dopamine agonists Drugs metabolized by COMT pathway may be affected (rare clinically)

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Therefore, because neurotransmitter imbalance contributes to depressive behaviors in patients with depression as described above, the appropriate modulation of neurotransmitters in the brain is key to treating depression ( Figure 2 )

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