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No studies have addressed whether dulaglutide could cross the BBB

Semaglutide works in the gut like the bodys natural GLP-1, slowing digestion, curbing hunger, and signaling fullness to the brain

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It was observed that the treatment of rats on a high-fat diet with exendin-4 resulted in a decrease in the number of osteoclasts and the area of eroded surfaces, while there was an increase in the osteoid area, bone mass, and trabecular bone volume

4.6 Ophthalmological effects 4.6.1 Glaucoma GLP-1R agonists exhibit anti-inflammatory and neuroprotective properties, suggesting they could also be beneficial in neurodegenerative diseases (73)

& Franco, J