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In target tissues, such as the liver and the brain, T 4 (the most abundant circulating thyroid hormone) can be converted to T 3 by selenium-containing enzymes known as iodothyronine deiodinases (DIOs) ( Figure 1
Weissman JR, et al
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However, the exact mechanism by which IGF-1 improves insulin signalling has not yet be explained (other than indirect actions through lipid clearance from the bloodstream by inhibiting GH (lipolysis on adipocytes) and FFA uptake by muscles
IV glutathione delivers GSH directly into the bloodstream for rapid availability
They work through completely different mechanisms, which is why many people find them complementary rather than overlapping
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