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For full prescribing details, refer to the electronic Medicines Compendium (eMC) Summary of Product Characteristics (SmPC) for each agent

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Most researchers notice subtle appetite changes within the first week, though some feel nothing at the starting dose

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Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011

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