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These transmembrane enzymes utilize NADPH to reduce O 2 , directly producing H 2 O 2 (as by NOX4, DUOX1/2) [72] or indirectly via O 2 generation (by NOX1-3) [73], which rapidly dismutates to H 2 O 2

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GHK-Cu is not approved by the FDA as a prescription medication for general therapeutic use

Without adequate collagen production and proper organization of collagen fibers, wounds heal with reduced strength and may be more prone to reopening or developing problematic scars

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