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These findings validate BCHep as a promising bioisosteric motif for meta -substituted arenes and naphthalenes, offering a balanced optimization of metabolic stability and biological activity and opening avenues to a wide range of potential applications in future medicinal chemistry programs

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BDNF detection: After GFP photomicrographs were acquired, slices were allowed to dehydrate, immersed in citrate buffer (2.1 g l 1 citric acid monohydrate, pH=6) and boiled for 15 min in a microwave

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