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Levels of the enzymes glutathione peroxidase and SOD and of the nonenzymatic components of the antioxidant system including reduced glutathione, ascorbic acid, -tocopherol, lycopene, and -carotene were significantly lower in children with asthma compared with the healthy controls

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J Clin Investig 117:16581669 Hillson JL, Furst DE (1997) Pharmacology and pharmacokinetics of methotrexate in rheumatic disease: practical issues in treatment and design

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