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NAFLD between genes and environment: what drives fibrogenesis

de la Cuesta-Zuluaga J, Mueller NT, Corrales-Agudelo V, Velsquez-Meja EP, Carmona JA, Abad JM, Escobar JS

The structural changes lower its affinity for IGF binding proteins and stretch its half-life to roughly 20-30 hours

10.1111/all.14949 105

This Perspectives article describes the biophysiology of ACTH, with an emphasis on its melanocortin actions, particularly in renal parenchymal cells, which could potentially explain the therapeutic effects of ACTH in nephrotic glomerulopathies

This can be consumed in 1-2 doses of 300mg/day Timing appears to be unimportant D